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To the human imagination, the heart is more than a muscle and thumping pump keeping us alive. From the Renaissance to the present, writers have helped us make sense of our bodies, in health and in illness or pain. The history of the heart, meanwhile, starts in Antiquity, where it shapes our beliefs about life. One of our aims will be to trace the historical, cultural, and subjective meanings our minds have given to this “sublime engine.” The other will be to discover how our scientifically inquisitive minds, backed up with technical skills and technological devices such as the stethoscope, have found new ways to take care of this volatile organ. Our materials will involve a constellation of texts in medical history, modern fiction in the form of poems and short-stories, and recent scientific prose on such topics as heart transplants, heart-monitoring implants, xenotransplants as well as heartbreaks.