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This First-Year Seminar analyzes issues and questions like: How did we arrive at the concept of the “gene”? What are the early observations that gave substance to this concept? How did we arrive at the “one gene, one enzyme” dogma? What is the chemical nature of the gene? Is DNA enough for regulated gene expression? Is it “all in our genes”? What is genetic plasticity and epigenetics? What about genomics and proteomics? In the course of our analyses we bring together observations, and experimental results and ideas not only from biological sciences (Genetics, Cell and Developmental Biology and Genetics) but also from Physics, Sociology, Politics and Philosophy. We do all this in order to clarify how observations turn to ideas, then dogmas and even biases that distort the true meaning of objective Sciences.