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This First-Year Seminar explores the scientific-technological, philosophical, social, and ethical dimensions of using animals for scientific research from the early nineteenth century to present. Why did scientists use animals and how did they choose “the right animal for the job”? How did philosophers define a “model organism”? What were the political economies formed within research communities sharing research animals? How did financial and material infrastructure take shape for large-scale, long-term maintenance of genetically standardized mice or zebrafish? How did the interpretations of animals reflect the social imaginaries of researchers and our society? And how did animals “speak” back? These are questions we are going to examine through reading scholarly publications, watching documentaries, visiting laboratories, and doing mini research projects together.