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This course will introduce current topics in cancer research with a focus on the current state of knowledge regarding pre-diagnosis concepts in cancer research. We will first provide students with the context in which to interpret the latest findings in cancer research by giving a brief overview of cancer biology and descriptive epidemiology of the most common cancers in the United States. We will then discuss the current state of knowledge regarding cancer etiology and primary prevention strategies, providing specific examples from research currently being conducted at the National Cancer Institute along with other emerging research in the field of cancer prevention. Finally, we will introduce students to concepts and research in cancer screening. We will employ multiple formats to promote student learning and to introduce different tools for research. These may include lectures, case studies, in-class discussions, online discussions, and select film and Internet resources.