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A seminar on current topics on signal transduction mechanisms underlying neuronal morphology, development and function. The proper functioning of the nervous system relies on the establishment of precise neuronal circuits through a developmental program including proliferation, neuronal migration, axonal growth, and neuronal survival. This course pertains to the extracellular cues and downstream neuronal signaling pathways that coordinate these key events during neuronal development. The course will also cover the role of aberrant signaling mechanisms in neuronal degeneration and disease.