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America’s scientific connections with China, its East Asian allies, and the rest of the world are heavily shaped by geopolitics nowadays. This course traces the historical root of these connections and invites you to explore the movement of knowledge and people, the omnipresence of the state and concerns about national security, and the career of Asian American students and scientists. It aims to equip you with a set of analytical tools to understand the complicated dynamics of the transnational scientific community between America and East Asian countries. As nationalism regains momentum globally, it is time to look back on history and think about how we should approach the increasingly tumultuous world!