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This research seminar invites students to consider the role of metaphor and analogy in histories of knowledge production. We will analyze primary sources associated with major and minor concepts from antiquity to the present. By taking a global and comparative approach to metaphor, this class examines the role of aesthetics in discursive and graphic articulations of optics, astronomy, physiology, anatomy, sphygmology, evolution, cognition, bacteriology, psychology, and beyond.