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The knowledge and practices of science and medicine are not as self-evident as they may appear. When we observe, what do we see? What counts as evidence? How does evidence become fact? How do facts circulate and what are their effects? Who is included in and excluded from our common-sense notions of science, medicine, and technology? This course will introduce students to central theoretical concerns in Science and Technology Studies and the Medical Humanities, focusing on enduring problematics that animate scholars. In conjunction with examinations of theoretical bases, students will learn to evaluate the methodological tools used in different fields in the humanities to study the production and circulation of scientific knowledge and the structures of medical care and public health. This problem-centered approach will help students understand and apply key concepts and approaches in critical studies of science, technology, and medicine.