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What is the relationship between the histories of music and scientific development? How is making music a kind of laboratory research? Musical instruments and aesthetics have always emerged in dialogue with developments in science, technology, and medicine. The first stethoscope borrowed from the design of flutes and challenged physicians to grapple with new concepts like "sound," "signal," and "noise." The automation of industrial machinery was influenced by earlier musical automata--technology that sought to mechanically synchronize, sequence and loop musical phrases. Concepts like logarithms, combinatorics, resonance and sympathetic vibration, melancholy and mania, etc., relied on the contributions of musicians, music theorists, and instrument-makers. This seminar looks at points of contact between music and histories of science, technology, and medicine through both scholarly and creative lenses. The course integrates creative and experimental music making with reading and short writing assignments. Familiarity with music notation and some basic musical skills will be helpful but are not strictly necessary. Limit 15 students.