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An advanced graduate level course that emphasizes the importance of molecules in astrophysical environments as diverse as interstellar clouds, circumstellar outflows, cometary comae, and active galactic nuclei. Topics will include the chemistry and photochemistry of astrophysical molecules; molecular excitation; astrophysical masers; interstellar molecular clouds; interstellar shock waves; circumstellar outflows; cometary comae; molecular accretion disks.