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This seminar explores the intellectual origins and ongoing intellectual productivity of the historical materialist account of political economy inaugurated with Karl Marx. It considers, in particular, how fatal couplings between power and difference are leveraged by capitalism as a tool of accumulation. Women’s labor and social reproduction, nature’s availability for mastery and the destructive exploitation of land and natural resources, racial inferiority and exploitative conditions of labor, and Global South peoples conscription into hyper-exploitative labor. The seminar will explore and interrogate the political dimensions of these transformations: how are relationships of political rule entangled with capitalist priorities of accumulation and which peoples/political subjects get to do the ruling and why? How did patriarchal and racial arrangements came to be, how do they relate to the production of value, and how are they sustained politically today? How do historical political transformations (including formal decolonization, democratic transitions, and the onset of free trade and structural adjustment, among others) inaugurate new forms of accumulation and how do these forms and their politics take different shape in the North and the Global South? A sample of the readings include Karl Marx, Rosa Luxemburg, W. E. B. Du Bois, Silvia Federici, Andreas Malm, Ruy Mauro Marini, and others.