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Johns Hopkins University | AS.197.209

Lessons from Transformative Advances

3.0

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Media routinely tout “revolutionary” medical advances that often fizzle. We will study the case histories of treatments and tests that have already proven to have profoundly altered medical practice and the healthcare industry. These case histories, drawn mainly from the last quarter of the 20th century, reveal patterns still common in medical innovation today. They show how protracted “multiplayer” innovations - not dramatic solitary leaps - typically produce transformational results. A framework of practical knowledge provides an overall guide to multiplayer innovation while the twists and turns of each story contain memorable lessons on their own. In addition to the core case histories, the course material includes: 1) Traditional ‘decision’ cases designed to develop skills in applying historical lessons; and 2) Readings on techniques that enable multiplayer innovation in any industry. Two introductory case histories exemplify the power and difficulties of multiplayer innovation: developing tests and treatments for HIV/AIDS and permanently curing ulcers with antibiotics (instead of treating them with antacids). The next three modules successively examine the development of life-changing drugs, devices, and surgical procedures.

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