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Systems Genome Biology uses predictive mathematical models to describe the physical principles behind biological function in the cell’s genome, including the nucleus and cellular and nuclear organelles, the chromatin and its folding structures, biomolecular complexes, and the individual molecules. Students will learn our current understanding at the systems level of biomolecular condensates, how omics data is analyzed and how it is used to understand cellular regulation and cell fate transitions, how epigenetics is coded in the genome, how DNA repairs its damages, and how all these phenomena are altered in cancer and neurodegenerative diseases as well as in rare diseases. The course will include guest lectures by leading scientists in these areas.