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Living systems require a constant flux of energy to perform their various functions. As such, they provide a unique opportunity to study the physics of systems out of equilibrium. This course covers topics in nonequilibrium biological physics including modeling fluctuations using Langevin, Fokker-Planck, and master equation formalisms, dissipation in driven systems, liquid-liquid phase separation, chromatin dynamics, epigenetic landscapes, and information flow in complex networks. Emphasis is placed on biological examples from cell and molecular biology and several lectures by domain experts will be interspersed with the course material. Recommended course background: Knowledge of equilibrium statistical mechanics.