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Most physicists and cosmologists still dream of a final theory for the cosmos, the one-inch mathematical formula that will explain... everything. From atoms to galaxies, from morals to daydreams. Is this possible? Can a single theory account for everything we see? Some physicists, such as Don Lincoln and Steven Weinberg believe so. Others, such as Lisa Randall and Carlo Rovelli are skeptical. In this course we will examine arguments for and against the existence of an all-encompassing theory from the point of view of philosophy and cosmology. We will read from a wide variety of sources, including popular science books, scientific articles, and classical texts in the philosophy of science. We will also trace the intellectual history of the notion of an all-encompassing theory in Western philosophy and in physics.