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An understanding of physiology is an invaluable part of any budding physicians repertoire. In this, the second of a two-part course introducing classical physiology in the human body, and how it functions in both health and disease, we will cover guts (renal, digestive, and immune systems), as well as hormones (basic endocrinology) and sex/reproductive physiology. In addition to classroom study, students will be challenged to synthesize their newfound knowledge by taking part in immersive afternoon activities. While this represents a wholly separate course, students should also consider taking the first part of this series (“Physiology & Disease: Core Systems) to bolster their understanding. Ultimately, knowledge of basic physiological processes should impact the student's future research and serve as a foundation for all future scientific and biomedical endeavors. There are no prerequisites for the course, but a background in biology is help.