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In this freshmen seminar we will explore instances of contact between different world cultures and pre-modern and modern science (16th-20th c.). The premise of the course is the understanding that in addition to the cultural, religious and political negotiations that took place during cross-cultural encounters, science also underwent a similar process. We understand science expansively, as the study of nature and the production of knowledge about it embedded in a particular cultural context. The historical episodes we will discuss are selections of instances where agents of the West—missionaries, explorers, businessmen, colonists, scientists—established prolonged contact with non-western cultures and engaged in conversations about their worldviews. Some cases considered include Jesuits in the Chinese imperial court, Spanish missionaries and the Maya, and English explorers in the Pacific islands.