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This foundational hybrid graduate laboratory course offers an interdisciplinary and state-of-the-art introduction to investigative approaches and experimental methods in biotechnology. It combines demonstrations of basic laboratory skills with virtual immersive technical training to introduce the application of standard laboratory methods and the use of equipment and techniques central to biotechnology research. Laboratory exercises highlight cutting-edge instrumentation currently used in the field. This course provides broad coverage of topics including cell and molecular biology, genetics, multi-omics, and more, providing students with the essential tools and knowledge to understand various applications in biotechnology research and development.