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Knowledge about neuronal structure, function, and circuitry will be applied in order to understand the genetic and molecular bases of a wide variety of diseases that affect the central and/or peripheral nervous systems. This course will incorporate explorations of the recent primary literature, as it relates to specific disease pathologies and treatments, and innovative research tools used in their study. The particular pathologies covered will vary by semester, but will include some of the following: brain/spinal cord injury, epilepsy, stroke, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, schizophrenia, depression/bipolar disorder, amyotrophic lateral sclerosis, Huntington’s disease, infectious disease, prion-based disease, addiction, autism spectrum disorder, and disorders of neural development. This course is a natural continuation of, and builds upon the foundations provided in, the Neurobiology course. Prerequisites: 410.601 Biochemistry, 410.602 Molecular Biology, 410.603 Advanced Cell Biology I, 410.604 Advanced Cell Biology II, 410.628 Neurobiology. SCI