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This course explores the interdisciplinary process of vaccine development, with a dual focus on computational design and biomanufacturing. Students will examine the immunological foundations of vaccination, including the roles of innate and adaptive immunity, and the mechanisms by which vaccines confer protection. The course emphasizes modern experimental and computational strategies in vaccine design that accelerate the identification and optimization of vaccine candidates. Innovative formulation technologies will be discussed alongside advances in delivery platforms such as lipid nanoparticles, needle-free systems, and plant-based or genetically modified food vectors. The course also provides an overview of the biomanufacturing pipeline—from preclinical development and scale-up to formulation, quality control, and regulatory approval. Emphasis is placed on both legacy production platforms and emerging technologies that enable rapid vaccine deployment in response to global health threats. Prerequisites: 410.603 Advanced Cell Biology or Equivalent, previous immunology course.