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Drug Design and Chemical Libraries explores pharmacological space with an emphasis on disciplines related to drug discovery, and an understanding of the properties desirable in a drug. Medicinal chemistry, natural product chemistry, focused synthetic libraries, and combinatorial chemistry will be covered. The application of Lipinski's rules for assessing drug-like molecules will be discussed in detail, as well as methods for chemical analysis, in silico drug design, molecular modeling, and compound storage and handling. Also, techniques used for assessing and harnessing chemical diversity for drug discovery will be discussed. Students will gain a fundamental understanding of small molecules at the atomic level as well as insights into the structure-activity relationship. Both are critical to the design and synthesis of chemical libraries that efficiently explore therapeutically useful chemical space and to drug design. Prerequisites: 410.603 Advanced Cell Biology or equivalent.