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During this course students examine the legal, ethical, and regulatory framework underlying most research activities in the U.S. Students discuss the trajectory of legal, ethical, regulatory and compliance issues affecting research administration, including the role of Congress, the role of the Executive Branch of government, and the role of federal and state agencies in the issuance and auditing of compliance regulations. Students will also discuss practical considerations for human subjects and animal research, financial conflict of interest, misconduct in science, export controls, safety and security and risk assessment.