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The course focuses on the role of blockchain technology in enhancing transparency and efficiency within global supply chains, with a particular emphasis on commercial paper processing, pharmaceutical tracking, and government public services. In this course, we review and discuss generational shifts in business through case studies revealing how industries are changing to adapt to the business risks and opportunities presented by megatrends like globalization, blockchain, and technology. Students will examine how distributed ledger technologies offer timely solutions to ongoing global disruptions, such as counterfeit pharmaceuticals, financial fraud, and inefficient public procurement.