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Advances in information and communication technologies, when coupled with advances in diagnostic and other medical technologies, have resulted in the emergence of new business models as well as new strategies for the delivery of health care to populations that are characterized by wide heterogeneity of wealth, education, and access to medical services. Health care providers—ranging from the large multi-specialty, tertiary-care-delivering hospitals to small physicians’ practices—need to be aware of the rapidly changing terrain of health care delivery and how the changing economics of care delivery can produce disruptive business practices by entities in the health care ecosystem.