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This is a new interdisciplinary course on leadership, decision making, and the application of ethics to real world problems. JHU students are future leaders of innovation across many fields, including but not limited to engineering, business, law, journalism, government, science and medicine. The goal of this new course is to give students a deep and practical grounding in how leaders make decisions, and in particular difficult decisions where there is no clearly right answer. In the first part of the course, we will cover important concepts in the practical application of ethics; in decision making; and leadership. In the second part of the course, we will take a deep look at major ethical issues resulting from the newfound capabilities made possible by emerging technologies. This term, the main question will be, should humans eliminate disease-carrying mosquitoes using gene editing technology? In future terms, the question will be different. The awesome power of emerging technologies to modify our world - our food supply, our health, even people - will only increase and become more pressing in coming years. Questions include: Is modifying wild animals ethical, on its face? Who gets to decide this, and how do they decide? Animals interact with humans and cross borders - can one jurisdiction (county, state or country) make changes to wild populations that would impact others? Both EN.500.496 and EN.500.497 are primarily a combination of online lectures, readings and substantial discussion components during the first 2/3rds of the semester. EN.500.496.01 also incorporates several small group meetings in the final weeks of the semesters.