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This course describes how nanomaterials have facilitated and will advance genetic medicine in clinical applications for disease treatment and prevention. Topics of this course include synthesis and structure-activity relationship of hard and soft nanoparticles, biomimetic nanomaterials, nanomaterials for nucleic acid delivery, nanomaterials for genome editor delivery, biological fate of nanomaterials, and nano-bio interface characterization. This course will have in-depth discussions on recent progress and publications in these areas.