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The course will review the recent advances in photonics technologies for medical imaging and sensing. The course is designed for graduate students with a back ground in optics and engineering. The main topics for the course are: Light Source and Devices for Biomedical Imaging; Fluorescence, Raman, Rayleigh Scatterings; Optical Endoscopy and Virtual biopsy; Novel imaging contrast dyes, nanoparticles, and optical clearing reagents; Label-free optical technologies in clinical applications; Neurophotonics and Optogenetics.