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This course will provide an overview of the cutting-edge biomedical microdevices, focusing on their engineering renovation. Students will study of Micro-electro-mechanical systems (MEMS) technology and its impact to biomedical devices. We will learn basic working mechanisms of different sensors, design and fabrication of biomedical microdevices. Examples of biomedical microdevices in clinical application and relevant engineering technologies behind them will be covered, for offering students with an interface between engineering and medicine. Students will learn how to apply fundamental engineering knowledge to solve challenges in healthcare applications.