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This advanced biomechanics course explores the mechanical behavior of key musculoskeletal tissues—ligaments, tendons, cartilage, and the intervertebral disc. Students will develop a deep understanding of the structure-function relationships in these anisotropic, heterogeneous tissues, examining how their unique compositions contribute to their biomechanical roles and susceptibilities to injury. Injuries of interest will include ACL tears, Achilles tendon injuries, and Intervertebral disc bulging. The course integrates concepts from materials science, including fiber-reinforced composite modeling and failure mechanisms such as yielding, fracture, and fatigue. Through analytical modeling, numerical simulations, and critical review of current literature, students will learn to apply composite theory to describe the layered, fiber-reinforced nature of musculoskeletal tissues, and use failure theory to predict the onset and progression of mechanical damage.