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Computational medicine is an emerging discipline in which computer models of disease are developed, constrained using data measured from individual patients, and then applied to deliver precision health care. This course will cover computational anatomy. Students will learn how to: model anatomies using magnetic resonance imaging data; compare anatomies via mappings onto anatomical atlases; discover anatomical biomarkers of disease; analyze changes in the connectivity of anatomies in disease. Class time will emphasize hands-on learning through data analysis, software development, and simulation. All instructional materials will be made available at the beginning of the course. Recommended Course Background: Matlab or Python. This course can be taken in conjunction with EN.580.433 which covers computational physiological medicine.