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Biomedical engineering has always involved interfacing with biological systems using non- or partially-biological devices. A current frontier is the ability to interface with biological systems from within using genetic systems. This course focuses on principles of engineering genetic systems. Students will learn how to design a genetic effector circuit, insert it cells and tissues, and assess its function. Specific concepts that will be covered include cellular engineering, gene editing, CRISPR, cloning, gene delivery, viral engineering, barcoding, genetic recording, spatial sequencing, and in situ sequencing.