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This course introduces biomedical engineering students to the challenges of engineering solutions for persons functioning with neural and physical disabilities in order to apply that knowledge to the development of a new, improved device to be used for measurements or treatments of an impairment or disability. Our objectives include: gaining a basic appreciation of disabilities such as loss of limb function (amputation) or sensory loss and correspondingly develop engineering solutions for helping persons with disabilities function – with prosthesis and neuroprosthesis/brain-machine interface as the central theme. Topics include: prosthesis design and its advances such as soft or hybrid prosthesis, computer-aided design and 3D printing, detection and analysis of muscle, nerve and brain signals to control the prosthesis, use of machine intelligence and AI to control the prosthesis, design of sensors and bio/neuro-inspired ways to analyze the sensor signals, methods to provide sensory feedback, use of motion tracking and virtual reality for human motion and performance, understand the nerve and brain architecture and the signals to detect sensory perceptions and use of these brain signals to build a brain-machine interface. This course can be partnered with EN.580.471/.771 Principles of Design of Medical Instrumentation. Recommended background: Circuits/Electronics, Signals, Systems & Controls, and Neuroscience coursework.