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Advances in magnetic resonance Imaging (MRI) have resulted in developing techniques such as diffusion imaging, delayed contrast enhanced imaging, tagged, flow map and many other imaging contrasts. These techniques offer insights into the structure and function of brain and other anatomical regions in the body. With increased availability of these techniques in clinical MRI machines, they are now entering clinical practice for the evaluation of disease. This course presents the underlying physical foundation of MRI, with a focus on more advanced techniques and their application in clinical research and practice. Topics that are covered include foundations of MRI (signal detection and construction, image contrast), diffusion weighted imaging, and cardiac imaging. Attention is also drawn to possible artifacts and pitfalls. Suggested course background: Signals and systems/multi-dimensional digital signal processing, differential equations, linear algebra. BME seniors permitted with instructor approval.