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In this course, students will review current literature on the most salient and interesting topics in the emerging field of Computational Medicine, which is focused on the development of quantitative approaches for understanding the mechanisms, diagnosis and treatment of human disease through applications of mathematics, engineering, and computational science. Whenever possible, the publications considered will be directly relevant to the lectures delivered by visiting scholars in the Institute for Computational Medicine’s seminar series. Students will be required to search for the most relevant papers in the current literature; read and critically interpret these papers; conduct interactive teaching sessions with the course instructor, other students, and trainees/faculty from the Institute. Potential topics will include: computational anatomy; computational molecular medicine; computational physiological medicine; and computational healthcare. Evaluation will be by the course instructor (pass/fail). Graduate level. Seniors by permission. All registrants must be approved by the course instructor.