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Public archives now contain petabytes of valuable but hard-to-analyze DNA sequencing data. Analyzing even small datasets is complicated by sequencing errors, differences between individuals, and the fragmentary nature of the the sequencing reads. In this course, we study recent algorithms and methods that seek to make sense of DNA sequencing datasets from small to very large. Topics covered will vary from year to year, but could include RNA sequencing data analysis, other functional genomics data analysis, metagenomics analysis, data compression, indexing, applications of streaming algorithms and sketch data structures, assembly, etc. There will be homework assignments and a course project. [Applications]