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Immunology studies defensive mechanisms of living organisms against external threats. Computational immunogenomics is a new field of bioinformatics that develops and applies computational approaches to the study and interpretation of immunological data, seeking to answer questions about adaptive immune responses in humans and important animals. In this course, students will learn how to design, apply, and benchmark algorithms for solving immunogenomics problems. [Applications] Students may receive credit for only one of EN.601.451, EN.601.651.