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Immunology studies defensive mechanisms of living organisms against external threats. Computational immunogenomics is a new branch of bioinformatics that develops and applies computational approaches to the study and interpretation of immunological data, seeking to answer questions about human adaptive immune responses to various pathogens, including but not limited to flu, HIV, and SARS-CoV-2. In this course, students will attend lectures and present immunogenomics papers in a journal club format.