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This course introduces fellows with a physics/engineering graduate background to modern concepts in molecular and cellular biology with examples taken from cancer immunology and cancer cell biology. Fundamentals and topics covered in this course include, but are not limited to: (i) molecular biology: control of gene expression, microarray technology and modern mol. biol. techniques, (ii) cancer cell transformation; metastasis; cancer genetics; (iii) cell membrane and organelles; (iv) evolution of lipid diversity; membrane structure and dynamics; (v) organization, dynamics, and function of the nucleus; (vi) the cytoskeleton and cancer cell migration; and (viii) ER-Golgi trafficking; traffic through the endosomal process; the fusion machinery; specificity and regulation of trafficking. Recommended Course Background: AS.020.306.