1.0

credits

Average Course Rating

This interactive class covers the 3D organization and dynamics of the cell nucleus and genome in health and disease. Topics include the nuclear envelope, lamina networks, nuclear pore complexes, nuclear import/export, LINC complexes, 3D chromosome organization, dynamic chromatin tethering, phase-partitioning, mitotic disassembly & reassembly of nuclear structure, and diseases (e.g., progeria, heart/muscle disease, brain disorders, metabolic disease) caused by mutations in nuclear lamina proteins. Students are expected to pre-watch lecture videos and come prepared for in-class discussion.