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This is a course about levels of understanding. On one level, it is a tour through some signal episodes in the history of biomedicine in the last 100 years or so: the discovery (or invention) of insulin; the revolution in human genetics; cancer; and others. On another level, it is about how one might go about understanding those and other episodes, Through the experiments and laboratory work? Via the clinic? From the patients who were either helped or not? These, of course, are themselves levels of analysis. On a third level, it is about discovering how you best understand something complicated like biomedicine---my hope is that this seminar will change the way you study what you study, whether it be science or history?