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This course explores efforts to contain disease epidemics across time and space, from the fourteenth-century black plague to recent epidemics of Ebola and Zika viruses. The course draws on historical materials from Europe, Asia, Africa, and Latin American and emphasizes the ways in which political, social, and economic institutions and practices influence how individuals and societies respond to the threat of disease epidemics. The course will also explore the various approaches that historians have taken to describe the history of epidemics.