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This graduate level advanced course focuses on the role of the immune system in human health and disease. It will expand upon basic immunologic principles to discuss the importance of the immune system both as a protector from and a cause of disease. Organ specific immune responses, human immune knockouts, and immune responses occurring in the setting of disease will be explored in a paired lecture and journal club format. This course is appropriate for graduate students and postdoctoral fellows who have completed a graduate level course in immunology.