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There is significant demand in both academia, research and industry for informatics professionals who are well versed in natural language processing (NLP). In this course, students will be oriented to the various applications of NLP in biomedicine, healthcare and public health. The course will emphasize the importance of clearly defining what problem needs to be solved or what questions one seeks to get answered via the use of NLP. Approaches to data mining of free text from the biomedical literature, clinical narratives, and other novel data sources will be covered. There will be opportunities for students to develop NLP and machine learning algorithms. Applications of these tools in epidemiologic surveillance, clinical decision support, and other relevant use cases will be covered.