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This course covers the molecular biology and genomics of both prokaryotes (using E. coli as the model organism) and eukaryotes, with a focus on "model organisms" including yeast, flies, worms, mice as well as humans. Both the molecular biology (reductionist) perspective and the genomics (systems biolgy) perspective will be provided on each topic, and there will be heavy emphasis on mechanism and regulation of fundamental processes in biological information transfer DNA->RNA->protein. This lecture module will cover genes and genomes, transcription and RNA world, replication, chromosome structure and function and genome instability.