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While the human genome sequence has been available for over a decade, it has become increasingly clear that epigenetic mechanisms are key to understanding gene regulation, cell differentiation, and disease states. Genome function appears to be governed by its architecture, including chromatin compaction, looping, long- and short-range chromosomal interactions, as well as interactions with sub-compartments such as the nuclear periphery. This course will present recent advances in epigenetics, including Chromatin Biochemistry, Cancer Epigenetics, Epigenetic Epidemiology and Epigenetic Pharmacology.