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In this course we will explore the history and uses of psychoactive compounds, the neurobiological basis of their activity, and their potential for healing. Along the way we will attempt to debunk some of the most common myths about this especially controversial class of drugs. Each session, one student will take the lead in discussing the assigned primary research articles (except for 2-3 documentary film sessions, which will take up the whole period). Beyond didactic learning, this graduate level course is designed to hone students’ skills in oral presentations, critical thinking, as well as composition and editing of manuscripts.