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Introduces the principles of functional magnetic resonance imaging (fMRI) as applied to human subjects research. Presents a theoretical overview of human fMRI research and includes key aspects of the design, data collection, processing, analysis and publication of a human subjects fMRI experiment. Focuses on describing all aspects of an fMRI study from the initial experimental design, through data collection and pre-processing, to statistical analysis. Describes the goals and limitations for fMRI studies, the data format and how it is processed prior to statistical analysis. Focuses on preforming individual subject and group level univariate statistical analysis of fMRI data with appropriate thresholding and multiple comparison correction. Weekly labs provide a practical application of these concepts to sample datasets and prepares students for the analysis of fMRI data.