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Continues where Principles and Methods of Functional Neuroimaging I (140.682) leaves off. Presents a theoretical overview of human fMRI research and includes key aspects of the design, data collection, processing, analysis and publication of a human subjects fMRI experiment. Focuses on multivariate statistical analysis of fMRI data. Describes both functional and effective connectivity analysis, graph-based analysis of fMRI data, and algorithms for performing brain decoding. Also discusses preparation of methods and results from fMRI experiments for peer-reviewed publication, and how to critically evaluate research methods and results of human subjects fMRI studies in the published literature. Provides a practical application of these concepts to sample fMRI datasets via weekly labs.