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Examines basic concepts of toxicology as they apply to the effects of environmental agents present in air, water and food (e.g. chemicals, metals) on public health. Discusses the distribution, cellular uptake, metabolism, and elimination of toxic agents, as well as the fundamental principles governing the interaction of foreign chemicals with biological systems. Considers how population data on disease incidence (various cancers, lung, kidney, heart, etc.) can suggest possible etiologies and how genetic and epigenetic factors can influence risk for adverse health effects. Focuses on the application of how these concepts provide evidence relevant to the understanding and prevention of morbidity and mortality resulting from environmental exposures to toxic substances through presentation of case studies.