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Reviews the mechanisms by which environmental toxicants cause chronic diseases such as cancer, COPD, asthma and heart diseases that impact public health. Includes topics: cell signaling pathways involved in oxidative and nitrosative stress, the microbiome, cell growth, cell death, DNA repair, inflammation and carcinogenesis in response to exposure to air pollutants, metals and other environmental toxicants. Presents most recent technological advances in the molecular and genetic tools available to study how environmental toxicants cause diseases, which includes omics technologies (genomics, proteomics and metabolomics), next-generation sequencing for gene expression and genetic variations, transgenic animals and emerging alternative animal models.